Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12644320 | 0.67 | SIGMAR1 (0.60) | SIGMAR1DRD2DRD1DRD4DRD5 | |
| SCHEMBL12539246 | 0.67 | GRM5 (0.44) | CYP2C19 | |
| SCHEMBL12549158 | 0.64 | PARP1 (0.43) | SIGMAR1DRD2DRD1DRD5DRD3 | |
| SCHEMBL25324704 | 0.64 | DRD2 (0.58) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL21662882 | 0.64 | DRD1 (0.45) | SIGMAR1DRD2DRD1DRD4DRD5 | |
| SCHEMBL7519149 | 0.64 | USP2 (0.36) | — | |
| SCHEMBL8023131 | 0.64 | DRD2 (0.40) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL1953079 | 0.63 | DRD1 (0.39) | SIGMAR1DRD2DRD1DRD5DRD3 | |
| Bromomethane SCHEMBL7768740 | 0.63 | ALDH1A1 (0.42) | SIGMAR1DRD2DRD1DRD4DRD5 | |
| SCHEMBL11668479 | 0.63 | SIGMAR1 (0.43) | SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |