Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8038473 | 0.96 | KDM4E (0.33) | KDM4EMEN1ALOX15KMT2AHSD17B10 | |
| Hydrochloric Acid SCHEMBL4634124 | 0.80 | ALDH1A1 (0.33) | MEN1KMT2A | |
| Bromide SCHEMBL8034463 | 0.76 | ALDH1A1 (0.33) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8034458 | 0.76 | — | — | |
| SCHEMBL8024871 | 0.73 | KDM4E (0.31) | KDM4EMEN1ALOX15KMT2AHSD17B10 | |
| Bromide SCHEMBL8040757 | 0.72 | — | — | |
| Bromide SCHEMBL8673204 | 0.72 | KDM4E (0.30) | KDM4EMEN1ALOX15KMT2AHSD17B10 | |
| SCHEMBL8034604 | 0.71 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL8024847 | 0.69 | — | — | |
| SCHEMBL8038477 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796875-B1 | Process for the preparation of crystalline vinylaromatic polymers with a predominant syndiotactic structure | ENICHEM SPA (IT) | 2000-03-29 | — | — | EP | disclosed |
| US-5721327-A | Process for the preparation of crystalline vinylaromatic polymers with a predominant syndiotactic structure | ENICHEM S.P.A. (IT) | 1998-02-24 | — | — | US | disclosed |
| EP-0796875-A2 | Process for the preparation of crystalline vinylaromatic polymers with a predominant syndiotactic structure | ENICHEM S.p.A. (IT) | 1997-09-24 | — | — | EP | disclosed |