Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.42 |
| ▸ | KCNK18 | Q7Z418 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013445 | 0.76 | MEN1 (0.46) | MEN1KMT2AALDH1A1L3MBTL1GAA | |
| SCHEMBL8026602 | 0.74 | DRD2 (0.47) | HTR1ADRD2DRD1HTR2AHTR7 | |
| SCHEMBL8028066 | 0.74 | CHEK1 (0.46) | ALDH1A1TDP1XDHIDO1AKR1C3 | |
| SCHEMBL8024458 | 0.74 | DRD2 (0.46) | HTR1ADRD2DRD1HTR2AHTR7 | |
| SCHEMBL8026339 | 0.72 | CHEK1 (0.46) | ALDH1A1TDP1XDHAKR1C3CHEK1 | |
| SCHEMBL3819347 | 0.70 | GPR35 (0.35) | KCNK2AKR1C3 | |
| SCHEMBL8028627 | 0.69 | DRD2 (0.55) | HTR1ADRD2DRD1HTR2AHTR7 | |
| SCHEMBL8025942 | 0.68 | HTR1A (0.46) | HTR1ADRD2DRD1HTR2AHTR7 | |
| SCHEMBL8027654 | 0.68 | DRD2 (0.46) | HTR1ADRD2DRD1HTR2AHTR7 | |
| SCHEMBL8034433 | 0.68 | DRD2 (0.48) | MEN1KMT2AHTR1ADRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |