Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010924 | 0.87 | MCL1 (0.52) | MAPTNPC1RAB9ALMNAGAA | |
| SCHEMBL8020988 | 0.85 | CYP4F2 (0.54) | MAPTNPC1RAB9ALMNAGAA | |
| SCHEMBL8010663 | 0.84 | BCL2L1 (0.67) | MAPTNPC1RAB9ALMNAGAA | |
| SCHEMBL31483496 | 0.80 | MAPT (0.49) | MAPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6824033 | 0.80 | MAPT (0.49) | MAPTNPC1RAB9ALMNAGAA | |
| SCHEMBL8021187 | 0.77 | DYRK1A (0.53) | MAPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6245982 | 0.77 | MAPT (0.52) | MAPTLMNAGAARXFP1TP53 | |
| SCHEMBL30099150 | 0.77 | LMNA (0.48) | MAPTNPC1RAB9ALMNAGAA | |
| SCHEMBL28836579 | 0.77 | LMNA (0.48) | MAPTNPC1RAB9ALMNAGAA | |
| SCHEMBL8021674 | 0.76 | TBXAS1 (0.74) | TP53SMN1; SMN2MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |
| EP-0921124-A1 | Benzothiophene derivatives useful in therapy | Pfizer Limited (GB) | 1999-06-09 | — | — | EP | disclosed |