Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 12/20 | 0.48 |
| ▸ | MTTP | P55157 | 11/20 | 0.48 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208303 | 0.83 | APOB (0.62) | APOBMTTPASIC3MELKSLC2A1 | |
| SCHEMBL6969471 | 0.79 | KEAP1 (0.44) | APOBMTTP | |
| SCHEMBL6974835 | 0.78 | ABCB1 (0.48) | APOBMTTP | |
| SCHEMBL6975613 | 0.78 | APOB (0.43) | APOBMTTPSMO | |
| SCHEMBL6964506 | 0.78 | APOB (0.44) | APOBMTTPSMO | |
| SCHEMBL6964486 | 0.77 | PLAU (0.46) | APOBMTTPJAK2JAK3PTK2 | |
| SCHEMBL6974831 | 0.77 | TMPRSS2 (0.42) | APOBMTTP | |
| Hydrochloric Acid SCHEMBL1187215 | 0.77 | EPHX2 (0.55) | ASIC3MELKSLC2A1 | |
| SCHEMBL6973499 | 0.76 | SMO (0.45) | APOBMTTPJAK2JAK3PTK2 | |
| SCHEMBL6962760 | 0.76 | APOB (0.44) | APOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975598-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBOXYLIC ACID (1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL)-AMIDE | PFIZER INC. (US) | 2000-02-02 | — | — | EP | disclosed |