Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 10/20 | 0.43 |
| ▸ | MTTP | P55157 | 10/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974219 | 0.89 | F10 (0.42) | APOBMTTPMGLLF10SMO | |
| SCHEMBL6964506 | 0.89 | APOB (0.44) | APOBMTTPMGLLSMO | |
| SCHEMBL6973825 | 0.87 | APOB (0.41) | APOBMTTPMGLLF10SMO | |
| SCHEMBL6967905 | 0.84 | APOB (0.41) | APOBMTTPMGLLF10GAA | |
| SCHEMBL8472708 | 0.83 | APOB (0.52) | APOBMTTPSMOGAAMAPT | |
| Xenalipin SCHEMBL9094220 | 0.78 | MTTP (0.40) | APOBMTTPRXRARXRBRXRG | |
| SCHEMBL8025148 | 0.78 | APOB (0.48) | APOBMTTPSMO | |
| SCHEMBL6974835 | 0.74 | ABCB1 (0.48) | APOBMTTPMGLLMAPT | |
| SCHEMBL8206850 | 0.72 | MTTP (0.58) | APOBMTTPSMOGAAMAPT | |
| SCHEMBL6974831 | 0.72 | TMPRSS2 (0.42) | APOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |