Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 6/20 | 0.31 |
| ▸ | HTR1A | P08908 | 3/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034433 | 0.75 | DRD2 (0.48) | MEN1CYP3A4KMT2ADRD2HTR1A | |
| SCHEMBL8030417 | 0.75 | MEN1 (0.44) | MEN1CYP3A4KMT2AMAOANOTUM | |
| SCHEMBL15445106 | 0.68 | DRD2 (0.35) | KMT2ADRD2HTR1ADRD3 | |
| SCHEMBL13948432 | 0.68 | DRD2 (0.35) | KMT2ADRD2HTR1ADRD3 | |
| SCHEMBL8024341 | 0.68 | MAOA (0.33) | MEN1CYP3A4KMT2AMAOAKDM4E | |
| SCHEMBL1011406 | 0.64 | HTR2B (0.35) | MAOAKDM4EGAAMAPTHTR2C | |
| SCHEMBL8034457 | 0.63 | MAOA (0.64) | MAOAKDM4EGAAHTR2CDRD2 | |
| SCHEMBL8024342 | 0.63 | MAOA (0.32) | MAOA | |
| SCHEMBL15241970 | 0.63 | TAS1R3 (0.32) | DRD2DRD3 | |
| SCHEMBL8030400 | 0.62 | MEN1 (0.42) | MEN1CYP3A4KMT2AKDM4ENOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |