Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029058 | 0.89 | MAOA (0.50) | MAOAALDH1A1KDM4EGAANPC1 | |
| SCHEMBL8028798 | 0.76 | HPGD (0.50) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL13548830 | 0.76 | CHRNB2 (0.50) | CHRNB2CHRNA4ALDH1A1KDM4EGAA | |
| SCHEMBL12608358 | 0.76 | HDAC6 (0.50) | ALDH1A1KDM4EGAANPC1HPGD | |
| SCHEMBL3440725 | 0.75 | MAOA (0.50) | MAOANPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13548841 | 0.75 | CHRNB2 (0.49) | CHRNB2CHRNA4ALDH1A1KDM4EGAA | |
| SCHEMBL8024197 | 0.75 | MAOA (0.60) | MAOASRD5A1DRD2DRD1DRD4 | |
| SCHEMBL2573314 | 0.75 | MTNR1B (0.46) | ALDH1A1KDM4EGAALMNAPOLB | |
| SCHEMBL17538340 | 0.74 | CHRNB2 (0.46) | CHRNB2CHRNA4ALDH1A1KDM4EGAA | |
| SCHEMBL22943673 | 0.74 | CHRNA7 (0.46) | CHRNB2CHRNA4ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |