Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018986 | 0.90 | HPGD (0.50) | HPGDPKML3MBTL1HSP90AA1HSP90AB1 | |
| SCHEMBL1010434 | 0.79 | HPGD (0.49) | HPGDPKML3MBTL1HSP90AA1HSP90AB1 | |
| SCHEMBL17324777 | 0.76 | HPGD (0.55) | HPGDPKML3MBTL1HSP90AA1HSP90AB1 | |
| SCHEMBL8025529 | 0.76 | MAOA (0.50) | HPGDKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8019057 | 0.76 | OPRM1 (0.50) | HPGDKDM4EALDH1A1MAPTHTT | |
| SCHEMBL8018984 | 0.75 | ALDH1A1 (0.47) | HPGDPKML3MBTL1KDM4EALDH1A1 | |
| SCHEMBL17324661 | 0.74 | HPGD (0.55) | HPGDPKML3MBTL1HSP90AA1HSP90AB1 | |
| SCHEMBL4566669 | 0.73 | HSD11B1 (0.45) | HPGDPKML3MBTL1HSP90AA1HSP90AB1 | |
| SCHEMBL21172706 | 0.72 | HPGD (0.49) | HPGDPKML3MBTL1HSP90AA1HSP90AB1 | |
| SCHEMBL1010981 | 0.72 | HPGD (0.49) | HPGDPKML3MBTL1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |