Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 5/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | CTSH | P09668 | 3/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8025635 | 1.00 | GSR (0.40) | GSRCTSBCTSKCTSHGRIK1 | |
| Cyclohexylamine SCHEMBL8025596 | 0.90 | GRIK1 (0.39) | GRIK1GRIK2TDP1 | |
| Cyclohexylamine SCHEMBL8025597 | 0.90 | GRIK1 (0.39) | GRIK1GRIK2TDP1 | |
| Cyclohexylamine SCHEMBL7798411 | 0.84 | RAB9A (0.38) | TDP1 | |
| Lysine SCHEMBL8035193 | 0.83 | GSR (0.43) | GSRCTSBCTSKCTSHDPP8 | |
| Lysine SCHEMBL8035194 | 0.83 | GSR (0.43) | GSRCTSBCTSKCTSHDPP8 | |
| Lysine SCHEMBL8039360 | 0.82 | CTSB (0.42) | GSRCTSBCTSKCTSHCTSL | |
| Lysine SCHEMBL8039357 | 0.82 | CTSB (0.42) | GSRCTSBCTSKCTSHCTSL | |
| Cyclohexylamine SCHEMBL7798273 | 0.81 | KMT2A (0.47) | TDP1 | |
| Lysine SCHEMBL8039122 | 0.81 | GSR (0.48) | GSRDPP8DPP7DPP9TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |