Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 2/20 | 0.59 |
| ▸ | GRM8 | O00222 | 1/20 | 0.51 |
| ▸ | GRM6 | O15303 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.43 |
| ▸ | ABAT | P80404 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8025700 | 1.00 | VCAM1 (0.59) | VCAM1GRM8GRM6GRM4GSR | |
| Lysine SCHEMBL8025630 | 0.82 | GSR (0.46) | GRM8GRM6GRM4GSRMAPT | |
| Lysine SCHEMBL8025632 | 0.82 | GSR (0.46) | GRM8GRM6GRM4GSRMAPT | |
| Lysine SCHEMBL7792526 | 0.81 | GSR (0.50) | GRM8GRM6GRM4GSR | |
| Cyclohexylamine SCHEMBL8035231 | 0.78 | VCAM1 (0.53) | VCAM1GRM8GRM6GRM4MAPT | |
| Cyclohexylamine SCHEMBL8035226 | 0.78 | VCAM1 (0.53) | VCAM1GRM8GRM6GRM4MAPT | |
| SCHEMBL560001 | 0.77 | VCAM1 (1.00) | VCAM1MAPTALDH5A1ABATMITF | |
| Lysine SCHEMBL8037517 | 0.77 | GRM4 (0.43) | GRM8GRM6GRM4GSRALDH5A1 | |
| Lysine SCHEMBL8037518 | 0.77 | GRM4 (0.43) | GRM8GRM6GRM4GSRALDH5A1 | |
| SCHEMBL28133984 | 0.76 | GRM8 (0.52) | VCAM1GRM8GRM6GRM4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |