Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GRM8 | O00222 | 8/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 8/20 | 0.42 |
| ▸ | GRM6 | O15303 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8025632 | 1.00 | GSR (0.46) | GSRMMP2KMT2AERN1MAPT | |
| Lysine SCHEMBL8025705 | 0.82 | VCAM1 (0.59) | GSRKMT2AMAPTGRM8GRM4 | |
| Lysine SCHEMBL8025700 | 0.82 | VCAM1 (0.59) | GSRKMT2AMAPTGRM8GRM4 | |
| Lysine SCHEMBL7792526 | 0.81 | GSR (0.50) | GSRMMP2GRM8GRM4GRM6 | |
| Dinitrophenylene SCHEMBL28977791 | 0.80 | KMO (0.58) | GSRMMP2GRM8GRM4GRM6 | |
| Glycine SCHEMBL8213987 | 0.80 | ERN1 (0.54) | KMT2AERN1MAPTHSD17B10 | |
| Lysine SCHEMBL28327845 | 0.78 | GSR (0.56) | GSRMMP2KMT2AMAPTGRM8 | |
| Lysine SCHEMBL28385610 | 0.78 | GSR (0.56) | GSRMMP2KMT2AMAPTGRM8 | |
| 2,4-Dinitrophenol SCHEMBL7081417 | 0.78 | ALDH1A1 (0.56) | GSRMMP2GRM8GRM4GRM6 | |
| Cyclohexylamine SCHEMBL8036033 | 0.78 | GAA (0.43) | KMT2AERN1MAPTKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |