SCHEMBL8026802

SCHEMBL8026802

CC(F)c1ncnc(NCc2ccccc2)c1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 3/20 0.50
CCNB2 O95067 2/20 0.50
CCNB1 P14635 2/20 0.50
CCNB3 Q8WWL7 2/20 0.50
CDK2 P24941 2/20 0.49
EGFR P00533 5/20 0.49
GALR3 O60755 2/20 0.49
NR2F2 P24468 2/20 0.49
RAB9A P51151 2/20 0.49
LMNA P02545 3/20 0.48
HTT P42858 2/20 0.48
TSHR P16473 2/20 0.48
MAPK1 P28482 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
KMT2A Q03164 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
PDE4A P27815 1/20 0.45
PDE4B Q07343 1/20 0.45
PDE4C Q08493 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8025396 0.89 CDK1 (0.50) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL8024318 0.89 EGFR (0.51) EGFRLMNAHTTMAPK1PDE5A
SCHEMBL8025185 0.87 PRMT1 (0.48) EGFRGALR3LMNAHTTKMT2A
SCHEMBL8485751 0.86 HTT (0.51) EGFRGALR3RAB9ALMNAHTT
SCHEMBL8024781 0.84 HTT (0.55) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL11110616 0.79 EGFR (0.54) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL9608226 0.76 CHRNB2 (0.38) EGFRRAB9ALMNATSHR
SCHEMBL7173843 0.75 GALR3 (0.55) EGFRGALR3NR2F2RAB9ALMNA
SCHEMBL7173846 0.75 GALR3 (0.55) EGFRGALR3NR2F2RAB9ALMNA
SCHEMBL8028223 0.75 GALR3 (0.55) EGFRGALR3NR2F2RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0543402-B1 Aralkylaminopyrimidine derivative, method for preparing the same and composition for controlling noxious organisms UBE INDUSTRIES (JP) 2000-03-01 EP claimed
US-5280025-A Aralkylaminopyrimidine derivative, and chemical for controlling noxious organisms containing the same UBE INDUSTRIES, LTD. (JP) 1994-01-18 US claimed
EP-0543402-A1 Aralkylaminopyrimidine derivative, method for preparing the same and chemical for controlling noxious organisms containing the same UBE INDUSTRIES, LTD. (JP) 1993-05-26 EP claimed
EP-0543402-B1 Aralkylaminopyrimidine derivative, method for preparing the same and composition for controlling noxious organisms UBE INDUSTRIES (JP) 2000-03-01 EP disclosed
US-5280025-A Aralkylaminopyrimidine derivative, and chemical for controlling noxious organisms containing the same UBE INDUSTRIES, LTD. (JP) 1994-01-18 US disclosed
EP-0543402-A1 Aralkylaminopyrimidine derivative, method for preparing the same and chemical for controlling noxious organisms containing the same UBE INDUSTRIES, LTD. (JP) 1993-05-26 EP disclosed