SCHEMBL8027655

SCHEMBL8027655

O=C(Nc1cccc2c(O)cccc12)C(Cl)Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV1 Q8NER1 4/20 0.57
▸ IDO1 P14902 2/20 0.54
▸ HPRT1 P00492 1/20 0.51
▸ CHEK1 O14757 1/20 0.50
▸ DAPK3 O43293 1/20 0.50
▸ PRKD3 O94806 1/20 0.50
▸ MAP4K4 O95819 1/20 0.50
▸ NTRK1 P04629 1/20 0.50
▸ RET P07949 1/20 0.50
▸ MET P08581 1/20 0.50
▸ PIM1 P11309 1/20 0.50
▸ FGFR1 P11362 1/20 0.50
▸ PDGFRA P16234 1/20 0.50
▸ LTK P29376 1/20 0.50
▸ GRK5 P34947 1/20 0.50
▸ MAPK8 P45983 1/20 0.50
▸ CSNK1A1 P48729 1/20 0.50
▸ CDK8 P49336 1/20 0.50
▸ CLK2 P49760 1/20 0.50
▸ GSK3A P49840 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8030732 0.90 IDO1 (0.67) TRPV1IDO1HPRT1ALDH1A1CDC25B
SCHEMBL26885099 0.83 IDO1 (0.62) TRPV1IDO1CHEK1DAPK3PRKD3
SCHEMBL10339293 0.82 KMT2A (0.62) HPRT1ALDH1A1GAAPDK1MEN1
SCHEMBL8017543 0.81 HPRT1 (0.50) TRPV1IDO1HPRT1ALDH1A1PDK1
SCHEMBL20498498 0.78 TRPV1 (0.59) TRPV1IDO1CHEK1DAPK3PRKD3
SCHEMBL19360781 0.78 IDO1 (0.56) TRPV1IDO1CHEK1DAPK3PRKD3
SCHEMBL1122552 0.77 TRPV1 (0.58) TRPV1IDO1CHEK1DAPK3PRKD3
SCHEMBL8026174 0.76 TRPV1 (0.54) TRPV1IDO1CHEK1DAPK3PRKD3
SCHEMBL8028208 0.76 ALDH1A1 (0.59) TRPV1CHEK1DAPK3PRKD3MAP4K4
SCHEMBL10217894 0.75 KDM4E (0.71) TRPV1CHEK1DAPK3PRKD3MAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0603954-B1 Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer JOHNSON & JOHNSON CLIN DIAG (US) 2000-03-08 — — EP disclosed
EP-0603953-B1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods JOHNSON & JOHNSON CLIN DIAG (US) 1999-02-17 — — EP disclosed
US-5736335-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1998-04-07 — — US disclosed
US-5641635-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1997-06-24 — — US disclosed
US-5372931-A Use of 4'-hydroxy- and 4'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods EASTMAN KODAK COMPANY (US) 1994-12-13 — — US disclosed
US-5372932-A Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide EASTMAN KODAK COMPANY (US) 1994-12-13 — — US disclosed
EP-0603953-A1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 — — EP disclosed
EP-0603954-A2 Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 — — EP disclosed
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