Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.48 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | LGMN | Q99538 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12853680 | 0.90 | TMEM97 (0.58) | TMEM97SIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL19537525 | 0.86 | TMEM97 (0.57) | TMEM97SIGMAR1ADRA2CSLC6A4MAOA | |
| SCHEMBL16695080 | 0.85 | MAOA (0.50) | TMEM97SIGMAR1SLC6A4ABHD6MAOA | |
| SCHEMBL10386636 | 0.80 | TMEM97 (0.58) | TMEM97SIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL10386377 | 0.80 | TMEM97 (0.58) | TMEM97SIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL21646504 | 0.77 | LGMN (0.49) | TMEM97SIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL12853747 | 0.77 | L3MBTL3 (0.51) | TMEM97SIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL12572450 | 0.77 | TMEM97 (0.58) | TMEM97SIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL19537604 | 0.77 | TMEM97 (0.59) | TMEM97SIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL14922321 | 0.77 | ALDH1A1 (0.63) | ADRA2CLGMNKDM4EMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |