Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 6/20 | 0.38 |
| ▸ | DRD5 | P21918 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022070 | 0.81 | MAOA (0.41) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8030417 | 0.79 | MEN1 (0.44) | ADRA2AADRA1ANOTUMMAOADRD2 | |
| SCHEMBL8027387 | 0.79 | GID4 (0.44) | MAOADRD1DRD2DRD5DRD4 | |
| SCHEMBL7978723 | 0.79 | GID4 (0.44) | ADRA2ACYP2D6ADRA1AMAOADRD1 | |
| SCHEMBL3290899 | 0.77 | CYP2D6 (0.56) | ADRA2AADRA2BADRA2CCYP2D6ADRA1D | |
| SCHEMBL8025971 | 0.77 | DRD2 (0.46) | ADRA2AADRA2BADRA2CCYP2D6ADRA1D | |
| SCHEMBL3285493 | 0.77 | CYP2D6 (0.56) | ADRA2AADRA2BADRA2CCYP2D6ADRA1D | |
| SCHEMBL8027390 | 0.77 | MAOA (0.53) | CYP2D6MAOADRD1DRD2DRD5 | |
| SCHEMBL3285034 | 0.77 | CYP2D6 (0.56) | ADRA2AADRA2BADRA2CCYP2D6ADRA1D | |
| SCHEMBL29339112 | 0.76 | DRD2 (0.47) | MAOADRD1DRD2DRD5DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |