Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022070 | 0.78 | MAOA (0.41) | DRD2DRD1NOTUMHTR1AMAOA | |
| SCHEMBL7978723 | 0.77 | GID4 (0.44) | DRD2DRD1DRD5HTR1AHTR7 | |
| SCHEMBL8028688 | 0.77 | ADRA2A (0.50) | DRD2DRD1DRD4DRD5NOTUM | |
| SCHEMBL8030417 | 0.77 | MEN1 (0.44) | DRD2NOTUMHTR1AHTR7MAOA | |
| SCHEMBL8027387 | 0.77 | GID4 (0.44) | DRD2DRD1DRD4DRD5HTR1A | |
| SCHEMBL8027390 | 0.74 | MAOA (0.53) | DRD2DRD1DRD4DRD5HTR1A | |
| SCHEMBL29339110 | 0.73 | DRD2 (0.46) | DRD2DRD1DRD4DRD5NOTUM | |
| SCHEMBL8011249 | 0.73 | NOTUM (0.44) | NOTUMMAOAHTR2CHTR2BPRCP | |
| SCHEMBL26161461 | 0.73 | MAOA (0.51) | DRD2DRD1DRD4DRD5HTR1A | |
| SCHEMBL29339112 | 0.73 | DRD2 (0.47) | DRD2DRD1DRD4DRD5HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |