Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.71 |
| ▸ | HTR1A | P08908 | 4/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029651 | 0.88 | SIGMAR1 (0.76) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL31061719 | 0.84 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8031431 | 0.84 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8029628 | 0.80 | SIGMAR1 (0.81) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8033233 | 0.79 | SIGMAR1 (0.76) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8035829 | 0.79 | HTR1A (0.65) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8029620 | 0.79 | SIGMAR1 (0.71) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8029887 | 0.78 | SIGMAR1 (0.83) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8031447 | 0.78 | SIGMAR1 (0.81) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8035775 | 0.78 | SIGMAR1 (0.81) | SIGMAR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1054848-C | New benzopyran derivatives, their process of preparation and pharmaceutical compositions which contain them | ADIR (FR) | 2000-07-26 | — | — | CN | disclosed |
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| CN-1132202-A | New benzopyran derivatives, their process of preparation and pharmaceutical compositions which contain them | ADIR (FR) | 1996-10-02 | — | — | CN | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |