Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043595 | 0.79 | GRM5 (0.51) | SMN1; SMN2KDM4ELMNAHTTKMT2A | |
| SCHEMBL8043602 | 0.79 | GRM5 (0.54) | SMN1; SMN2KDM4ELMNAHTTKMT2A | |
| SCHEMBL8032107 | 0.78 | HIF1A (0.45) | SMN1; SMN2KDM4ELMNAHTTHIF1A | |
| SCHEMBL8041606 | 0.77 | HIF1A (0.51) | SMN1; SMN2KDM4ELMNAHTTHIF1A | |
| SCHEMBL8043531 | 0.77 | METAP1 (0.49) | SMN1; SMN2KDM4ELMNAHTTKMT2A | |
| SCHEMBL8045505 | 0.77 | HIF1A (0.45) | SMN1; SMN2KDM4ELMNAHTTHIF1A | |
| SCHEMBL8043609 | 0.76 | HIF1A (0.47) | SMN1; SMN2KDM4ELMNAHTTHIF1A | |
| SCHEMBL8043558 | 0.75 | TRPV1 (0.46) | SMN1; SMN2KDM4ELMNAHTTTDP1 | |
| SCHEMBL8043507 | 0.74 | NPC1 (0.43) | SMN1; SMN2KDM4ELMNAHTTHIF1A | |
| SCHEMBL8043588 | 0.74 | HIF1A (0.43) | SMN1; SMN2KDM4ELMNAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |