Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044541 | 0.85 | ALOX15 (0.41) | HSD17B10GABRA5GABRB2RAB9ASMN1; SMN2 | |
| SCHEMBL8042994 | 0.85 | GABRA5 (0.41) | HSD17B10GABRA5GABRB2RAB9ASMN1; SMN2 | |
| SCHEMBL8043409 | 0.84 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2RAB9ASMN1; SMN2 | |
| SCHEMBL8044815 | 0.84 | GABRA5 (0.40) | HSD17B10GABRA5GABRB2RAB9ASMN1; SMN2 | |
| SCHEMBL8044066 | 0.83 | HTT (0.45) | HSD17B10GABRA5GABRB2LMNAALDH1A1 | |
| SCHEMBL8051238 | 0.83 | HSD17B10 (0.42) | HSD17B10GABRA5GABRB2RAB9ASMN1; SMN2 | |
| SCHEMBL8033866 | 0.81 | HSD17B10 (0.40) | HSD17B10GABRA5GABRB2LMNAALDH1A1 | |
| SCHEMBL8051833 | 0.80 | POLB (0.54) | HSD17B10SMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL8046497 | 0.79 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2RAB9ASMN1; SMN2 | |
| SCHEMBL8050055 | 0.79 | SMN1; SMN2 (0.47) | HSD17B10GABRA5GABRB2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |