Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050055 | 0.79 | SMN1; SMN2 (0.47) | HSD17B10GABRA5GABRB2LMNARAB9A | |
| SCHEMBL8032345 | 0.79 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2LMNARAB9A | |
| SCHEMBL8042846 | 0.76 | HSD17B10 (0.40) | HSD17B10GABRA5GABRB2LMNARAB9A | |
| SCHEMBL8044541 | 0.75 | ALOX15 (0.41) | HSD17B10GABRA5GABRB2LMNAPOLB | |
| SCHEMBL8042994 | 0.74 | GABRA5 (0.41) | HSD17B10GABRA5GABRB2LMNAPOLB | |
| SCHEMBL8033896 | 0.74 | NPC1 (0.54) | HSD17B10POLBRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL8044648 | 0.74 | HSD17B10 (0.50) | HSD17B10GCKLMNAPOLBAPEX1 | |
| SCHEMBL8033980 | 0.74 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2LMNAPOLB | |
| SCHEMBL9332045 | 0.74 | HSD17B10 (0.56) | HSD17B10GABRA5GABRB2LMNARAB9A | |
| SCHEMBL8044815 | 0.73 | GABRA5 (0.40) | HSD17B10GABRA5GABRB2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |