Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044066 | 0.93 | HTT (0.45) | ALOX15HSD17B10KMT2AGABRA5GABRB2 | |
| SCHEMBL8042994 | 0.90 | GABRA5 (0.41) | HSD17B10KMT2AGABRA5GABRB2ALDH1A1 | |
| SCHEMBL8051238 | 0.86 | HSD17B10 (0.42) | HSD17B10KMT2AGABRA5GABRB2ALDH1A1 | |
| SCHEMBL8033866 | 0.85 | HSD17B10 (0.40) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL8032345 | 0.85 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2ALDH1A1NPC1 | |
| SCHEMBL8044409 | 0.84 | ALDH1A1 (0.40) | HSD17B10KMT2AGABRA5GABRB2ALDH1A1 | |
| SCHEMBL8033871 | 0.83 | HSD17B10 (0.36) | HSD17B10KMT2AGABRA5GABRB2ALDH1A1 | |
| SCHEMBL8032934 | 0.81 | ALDH1A1 (0.50) | KMT2AALDH1A1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8044815 | 0.80 | GABRA5 (0.40) | HSD17B10KMT2AGABRA5GABRB2ALDH1A1 | |
| SCHEMBL8043409 | 0.80 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |