Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050220 | 0.84 | MAPT (0.43) | ALDH1A1HPGDSMN1; SMN2POLBHSD17B10 | |
| SCHEMBL8045150 | 0.83 | ALDH1A1 (0.52) | ALDH1A1HPGDSMN1; SMN2TSHRPOLB | |
| SCHEMBL8044261 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HPGDSMN1; SMN2TSHRPOLB | |
| SCHEMBL8034157 | 0.82 | AKR1B1 (0.42) | ALDH1A1HPGDSMN1; SMN2MAPK1AKR1B1 | |
| SCHEMBL8050578 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HPGDSMN1; SMN2TSHRPOLB | |
| SCHEMBL8044630 | 0.81 | PDK1 (0.53) | ALDH1A1HPGDSMN1; SMN2TSHRMAPK1 | |
| SCHEMBL8043976 | 0.81 | KDM4E (0.43) | ALDH1A1HPGDSMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL8049808 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1HPGDSMN1; SMN2TSHRPOLB | |
| SCHEMBL8032720 | 0.79 | HSP90AA1 (0.53) | ALDH1A1HPGDSMN1; SMN2TSHRPOLB | |
| SCHEMBL8048335 | 0.79 | RAB9A (0.45) | ALDH1A1HPGDSMN1; SMN2TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |