Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044036 | 0.90 | KMT2A (0.44) | RAB9ANPC1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL8043688 | 0.84 | HTR1A (0.46) | RAB9ANPC1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL8048583 | 0.83 | ALDH1A1 (0.45) | RAB9ATDP1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8048771 | 0.82 | MAPT (0.37) | NPC1KMT2AMEN1MAPTCYP1A2 | |
| SCHEMBL8034187 | 0.82 | HTR1A (0.44) | RAB9ANPC1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL8043865 | 0.81 | RAB9A (0.42) | RAB9ANPC1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL8043746 | 0.80 | SMN1; SMN2 (0.43) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8033580 | 0.80 | POLB (0.44) | RAB9ANPC1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL8050306 | 0.79 | LMNA (0.41) | RAB9ANPC1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL8051238 | 0.79 | HSD17B10 (0.42) | RAB9ANPC1TDP1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |