Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032636 | 0.87 | ATM (0.47) | ATMSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL8033827 | 0.85 | TSHR (0.52) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL8032500 | 0.82 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL8044765 | 0.82 | RPA1 (0.41) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL8050081 | 0.82 | TSHR (0.48) | ATMSMN1; SMN2TSHRHTTTERT | |
| SCHEMBL8051011 | 0.81 | EIF4E (0.35) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL8051217 | 0.81 | EIF4E (0.36) | SMN1; SMN2ALDH1A1KDM4EKMT2ATSHR | |
| SCHEMBL8032690 | 0.81 | KDM4E (0.45) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL8051302 | 0.79 | ATM (0.48) | ATMSMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL8050964 | 0.79 | ALPG (0.40) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |