Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032740 | 0.86 | ALDH1A1 (0.39) | HTR6ALDH1A1GAAMMP2MAPT | |
| SCHEMBL8465404 | 0.83 | HTR6 (0.51) | HTR6KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8032662 | 0.75 | LMNA (0.45) | KMT2ASMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL8032658 | 0.75 | LMNA (0.45) | KMT2ASMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL8466244 | 0.73 | KMT2A (0.53) | HTR6KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13964526 | 0.71 | HTR6 (0.63) | HTR6KMT2AALDH1A1POLBCYP3A4 | |
| SCHEMBL13964681 | 0.71 | HTR6 (0.57) | HTR6KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29130764 | 0.70 | METAP1 (0.64) | — | |
| SCHEMBL28549773 | 0.70 | MMP2 (0.48) | SMN1; SMN2ALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL13964525 | 0.69 | HTR6 (0.64) | HTR6KMT2AALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |