Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034048 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL8052083 | 0.84 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL8047964 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL8033827 | 0.82 | TSHR (0.52) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL8044252 | 0.81 | ATM (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2EIF4E | |
| SCHEMBL8032500 | 0.80 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDCYP1A2SMN1; SMN2 | |
| SCHEMBL8044765 | 0.80 | RPA1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2EIF4E | |
| SCHEMBL8051011 | 0.80 | EIF4E (0.35) | KDM4EALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL8051217 | 0.80 | EIF4E (0.36) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL8050964 | 0.77 | ALPG (0.40) | KDM4EALDH1A1HPGDCYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |