SCHEMBL8032889

SCHEMBL8032889

CCOC(=O)CCc1nnc(Sc2ncc(Cl)s2)s1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.37
GAA P10253 2/20 0.35
HPGD P15428 2/20 0.35
KAT2B Q92831 1/20 0.35
CYP4F2 P78329 2/20 0.35
CYP4A11 Q02928 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
POLB P06746 2/20 0.34
KDM4E B2RXH2 2/20 0.34
RECQL P46063 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
MAPT P10636 1/20 0.33
HSD17B10 Q99714 2/20 0.33
CCNB2 O95067 1/20 0.33
CCNE2 O96020 1/20 0.33
CDK1 P06493 1/20 0.33
CDK4 P11802 1/20 0.33
CCNB1 P14635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8042807 0.88 MEN1 (0.44) ALDH1A1GAAHPGDSMN1; SMN2MEN1
SCHEMBL8044854 0.85 RXRA (0.39) ALDH1A1GAAHPGDCYP4F2CYP4A11
SCHEMBL8051075 0.83 ALDH1A1 (0.35) ALDH1A1GAAHPGDCYP4F2CYP4A11
SCHEMBL8044126 0.83 HDAC6 (0.36) ALDH1A1
SCHEMBL8032504 0.82 MAPK8 (0.54) ALDH1A1HPGDMEN1KMT2ATDP1
SCHEMBL8042395 0.80 ALDH1A1 (0.38) ALDH1A1GAAHPGDCYP4F2CYP4A11
SCHEMBL8043004 0.80 MAPK8 (0.39) ALDH1A1GAASMN1; SMN2KMT2APOLB
SCHEMBL8043002 0.79 MEN1 (0.43) ALDH1A1GAAHPGDCYP4F2CYP4A11
SCHEMBL8044324 0.79 ALDH1A1 (0.37) ALDH1A1TSHR
SCHEMBL8044142 0.78 ALDH1A1 (0.47) ALDH1A1GAAHPGDSMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed
WO-1998027092-A1 THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION SUGEN, INC. (US) 1998-06-25 WO disclosed