Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044324 | 0.93 | ALDH1A1 (0.37) | MAPK8MAPK9MAPK10ALDH1A1 | |
| SCHEMBL8043915 | 0.88 | MAPK8 (0.37) | MAPK8MAPK9MAPK10POLBKMT2A | |
| SCHEMBL8044265 | 0.85 | MAPK8 (0.32) | MAPK8MAPK9MAPK10 | |
| SCHEMBL8043957 | 0.81 | MAPK8 (0.33) | MAPK8MAPK9MAPK10 | |
| SCHEMBL8051775 | 0.81 | POLB (0.40) | MAPK8MAPK9SMN1; SMN2MAPK10POLB | |
| SCHEMBL8044126 | 0.80 | HDAC6 (0.36) | MAPK8MAPK9MAPK10ALDH1A1 | |
| SCHEMBL8043927 | 0.80 | ATM (0.47) | SMN1; SMN2POLBKMT2ANPC1ALDH1A1 | |
| SCHEMBL8032889 | 0.80 | ALDH1A1 (0.37) | SMN1; SMN2POLBGAAKMT2AALDH1A1 | |
| SCHEMBL8044684 | 0.77 | RXRA (0.42) | MAPK8MAPK9POLBGLAGAA | |
| SCHEMBL8048119 | 0.77 | MAPK8 (0.38) | MAPK8MAPK9MAPK10POLBGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |