Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12872225 | 1.00 | MAT2A (0.35) | MAT2AALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL9273336 | 0.89 | PHGDH (0.37) | ALDH1A1KDM4ESMN1; SMN2LMNADRD3 | |
| SCHEMBL1186775 | 0.89 | PHGDH (0.37) | ALDH1A1KDM4ESMN1; SMN2LMNADRD3 | |
| SCHEMBL12872295 | 0.87 | TRPV3 (0.39) | ALDH1A1KDM4ESMN1; SMN2LMNAHTR3A | |
| SCHEMBL12872284 | 0.87 | HRH4 (0.38) | KDM4ELMNAHTR3AHRH4MAPT | |
| SCHEMBL8034806 | 0.87 | HRH4 (0.38) | KDM4ELMNAHTR3AHRH4MAPT | |
| SCHEMBL3046737 | 0.86 | HTR3A (0.36) | ALDH1A1KDM4ESMN1; SMN2HTR2AHTR3A | |
| SCHEMBL3046733 | 0.86 | HTR3A (0.36) | ALDH1A1KDM4ESMN1; SMN2HTR2AHTR3A | |
| SCHEMBL9267989 | 0.86 | TLR8 (0.35) | MAT2AALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL12872285 | 0.84 | HTR3A (0.34) | ALDH1A1KDM4EHTR3AHRH4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214673-B1 | PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2012-05-30 | — | — | EP | disclosed |
| WO-2009053268-A1 | NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-30 | — | — | WO | disclosed |