Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXN | P10599 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042627 | 0.82 | ALDH1A1 (0.42) | ALDH1A1HPGDTDP1CYP1A2CYP2D6 | |
| SCHEMBL8043823 | 0.81 | ALDH1A1 (0.53) | ALDH1A1HPGDTDP1CYP1A2CYP2D6 | |
| SCHEMBL8044907 | 0.80 | ALDH1A1 (0.47) | ALDH1A1HPGDTDP1CYP1A2KMT2A | |
| SCHEMBL8033846 | 0.80 | PDK1 (0.52) | ALDH1A1TDP1CYP1A2KMT2AMEN1 | |
| SCHEMBL8046056 | 0.78 | ALDH1A1 (0.51) | ALDH1A1HPGDTDP1CYP1A2CYP2D6 | |
| SCHEMBL31399947 | 0.77 | ALDH1A1 (0.47) | ALDH1A1HPGDTDP1CYP1A2CYP2D6 | |
| SCHEMBL8044271 | 0.76 | RAB9A (0.62) | ALDH1A1HPGDTDP1CYP1A2CYP2D6 | |
| SCHEMBL8043605 | 0.75 | MEN1 (0.45) | ALDH1A1HPGDTDP1CYP1A2CYP2D6 | |
| SCHEMBL31399986 | 0.74 | ALDH1A1 (0.43) | ALDH1A1HPGDTDP1CYP1A2CYP2D6 | |
| SCHEMBL8046562 | 0.74 | ALDH1A1 (0.70) | ALDH1A1HPGDTDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |