Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 10/20 | 0.52 |
| ▸ | CA9 | Q16790 | 9/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16302105 | 0.86 | CA12 (0.68) | GAAHDAC1HDAC4HDAC7HDAC8 | |
| SCHEMBL11996290 | 0.83 | GAA (0.55) | GAAHDAC1HDAC4HDAC7HDAC8 | |
| SCHEMBL8066070 | 0.83 | HTT (0.57) | HDAC1HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL13865506 | 0.82 | CA12 (0.72) | GAAHDAC1HDAC4HDAC7HDAC8 | |
| SCHEMBL8066228 | 0.78 | HTT (0.48) | HTTTSHR | |
| SCHEMBL7913026 | 0.77 | PDE4B (0.43) | HDAC4HDAC8HTR7HDAC2HTT | |
| SCHEMBL8068535 | 0.77 | HDAC7 (0.49) | HDAC4HDAC7HDAC8HDAC2HTT | |
| SCHEMBL24579678 | 0.75 | HDAC1 (0.76) | GAAHDAC1HDAC4HDAC7HDAC8 | |
| SCHEMBL8071515 | 0.75 | HDAC7 (0.45) | HDAC4HDAC7HDAC8HDAC2HTT | |
| SCHEMBL8065440 | 0.74 | RXFP1 (0.57) | HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2628727-A2 | Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders | Decode Genetics EHF (IS) | 2013-08-21 | — | — | EP | disclosed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |