Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | TLR5 | O60602 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042649 | 0.88 | ALDH1A1 (0.36) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8050060 | 0.83 | HTT (0.46) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8051017 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8042069 | 0.79 | LMNA (0.40) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8043237 | 0.79 | TSHR (0.39) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8043948 | 0.79 | ALDH1A1 (0.39) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8042081 | 0.78 | TSHR (0.44) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8051092 | 0.77 | ATM (0.47) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL8042794 | 0.77 | TSHR (0.59) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8048173 | 0.77 | MAPT (0.36) | ALDH1A1TSHRMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |