Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TLR5 | O60602 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044387 | 0.85 | TSHR (0.37) | TSHRALDH1A1MEN1KMT2ASIRT2 | |
| SCHEMBL8043019 | 0.85 | HDAC6 (0.38) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8047165 | 0.83 | NPC1 (0.44) | TSHRALDH1A1MEN1KMT2ASIRT2 | |
| SCHEMBL8043803 | 0.81 | HDAC6 (0.41) | TSHRHSD17B10PKMPOLBMAPT | |
| SCHEMBL8042081 | 0.81 | TSHR (0.44) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8051017 | 0.79 | ALDH1A1 (0.41) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8042069 | 0.79 | LMNA (0.40) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8050060 | 0.79 | HTT (0.46) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8034059 | 0.79 | ALDH1A1 (0.39) | TSHRALDH1A1MEN1KMT2ASIRT2 | |
| SCHEMBL8042581 | 0.78 | ATM (0.47) | TSHRALDH1A1MEN1KMT2ATERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |