Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8039286 | 0.87 | PPARG (0.67) | PPARGJAK2JAK1TYK2JAK3 | |
| SCHEMBL4532827 | 0.85 | PPARG (0.68) | PPARGKDM4ERORC | |
| SCHEMBL8036202 | 0.83 | PPARG (0.65) | PPARGKDM4E | |
| SCHEMBL8039653 | 0.82 | PPARG (0.66) | PPARGKDM4E | |
| SCHEMBL4540880 | 0.82 | PPARG (0.50) | PPARGKDM4E | |
| SCHEMBL8037645 | 0.79 | PPARG (1.00) | PPARG | |
| SCHEMBL8037684 | 0.79 | PPARG (1.00) | PPARG | |
| SCHEMBL8025911 | 0.75 | KDM4E (0.70) | PPARGKDM4E | |
| SCHEMBL2100541 | 0.74 | KDM4E (0.55) | PPARGKDM4E | |
| SCHEMBL4535196 | 0.73 | PPARG (0.72) | PPARGRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083526-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |