Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.67 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK1 | P23458 | 5/20 | 0.49 |
| ▸ | TYK2 | P29597 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 5/20 | 0.49 |
| ▸ | CCR2 | P41597 | 4/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | RHEB | Q15382 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035322 | 0.87 | PPARG (0.65) | PPARGJAK2JAK1TYK2JAK3 | |
| SCHEMBL4535196 | 0.83 | PPARG (0.72) | PPARGCCR2TBXA2RRHEB | |
| SCHEMBL8040521 | 0.81 | PPARG (0.68) | PPARGCCR2TBXA2R | |
| SCHEMBL8037645 | 0.81 | PPARG (1.00) | PPARG | |
| SCHEMBL8037684 | 0.81 | PPARG (1.00) | PPARG | |
| SCHEMBL8028794 | 0.80 | PPARG (0.69) | PPARGCCR2ABCB11TBXA2R | |
| SCHEMBL8028791 | 0.79 | PPARG (0.69) | PPARGCCR2ABCB11TBXA2RRHEB | |
| SCHEMBL6243182 | 0.79 | AGTR1 (0.61) | PPARGTBXA2R | |
| SCHEMBL6242822 | 0.74 | USP2 (0.60) | PPARGTBXA2R | |
| SCHEMBL6307747 | 0.74 | CCR2 (0.81) | CCR2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083526-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |