Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025399 | 0.91 | TOP2A (0.51) | TOP2AHTTHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL8035060 | 0.87 | KMT2A (0.48) | TOP2AHTTHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL16887761 | 0.87 | HTT (0.61) | TOP2AHTTHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL8025349 | 0.80 | ALDH1A1 (0.47) | TOP2AHTTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1030263 | 0.73 | LMNA (0.74) | HTTALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL2087952 | 0.73 | CETP (0.67) | TOP2AALDH1A1KDM4ELMNAALOX12 | |
| SCHEMBL16887763 | 0.73 | ATM (0.48) | HTTHSD17B10ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL18347806 | 0.73 | MEN1 (0.49) | HTTHSD17B10ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8495853 | 0.73 | CETP (0.47) | ALDH1A1SMN1; SMN2KDM4ELMNAALOX12 | |
| SCHEMBL1358972 | 0.72 | CETP (0.54) | TOP2AHTTHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993449-A1 | QUINOLINE DERIVATIVES AS PDE IV AND/OR TNF INHIBITORS | Darwin Discovery Limited (GB) | 2000-04-19 | — | — | EP | claimed |
| WO-1998057936-A1 | QUINOLINE DERIVATIVES AS PDE IV AND/OR TNF INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1998-12-23 | — | — | WO | claimed |
| US-6069151-A | Quinolines and their therapeutic use | DARWIN DISCOVERY, LTD. (GB) | 2000-05-30 | — | — | US | disclosed |
| EP-0993449-A1 | QUINOLINE DERIVATIVES AS PDE IV AND/OR TNF INHIBITORS | Darwin Discovery Limited (GB) | 2000-04-19 | — | — | EP | disclosed |
| WO-1998057936-A1 | QUINOLINE DERIVATIVES AS PDE IV AND/OR TNF INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1998-12-23 | — | — | WO | disclosed |