Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035560 | 0.91 | TOP2A (0.48) | TOP2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8025349 | 0.89 | ALDH1A1 (0.47) | TOP2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL16887761 | 0.82 | HTT (0.61) | TOP2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30365402 | 0.79 | TOP2A (0.57) | TOP2AKDM4EALDH1A1MAPK1ATM | |
| SCHEMBL8035060 | 0.78 | KMT2A (0.48) | TOP2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4697930 | 0.75 | PDE4A (0.70) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL18347692 | 0.74 | SLC40A1 (0.51) | TOP2APDE4DSMN1; SMN2 | |
| SCHEMBL1030263 | 0.73 | LMNA (0.74) | KDM4ELMNAALOX12ALDH1A1GAA | |
| SCHEMBL2087952 | 0.73 | CETP (0.67) | TOP2AKDM4ELMNAALOX12ALDH1A1 | |
| SCHEMBL8495853 | 0.73 | CETP (0.47) | KDM4ELMNAALOX12ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6069151-A | Quinolines and their therapeutic use | DARWIN DISCOVERY, LTD. (GB) | 2000-05-30 | — | — | US | claimed |