Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035619 | 0.86 | POLB (0.53) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL27704908 | 0.84 | MAPT (0.47) | L3MBTL1MAPK1HSD11B1NPC1RAB9A | |
| SCHEMBL8035614 | 0.82 | POLB (0.55) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL7794004 | 0.81 | NPC1 (0.60) | L3MBTL1LMNAHSD11B1NPC1RAB9A | |
| SCHEMBL6518191 | 0.77 | SMN1; SMN2 (0.41) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL7315604 | 0.76 | CES2 (0.50) | LMNARAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL338742 | 0.75 | SMN1; SMN2 (0.61) | LMNAPTPN1ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL6519690 | 0.75 | NPC1 (0.45) | LMNAHSD11B1NPC1RAB9AALDH1A1 | |
| SCHEMBL682591 | 0.74 | L3MBTL1 (0.67) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL21269769 | 0.73 | SMN1; SMN2 (0.59) | LMNAPTPN1ALDH1A1SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1082370-C | Pharmaceutical composition containing 4-oxo-butyric acid | MERCK PATENT GMBH (DE) | 2002-04-10 | — | — | CN | disclosed |
| US-6143787-A | HETEROCYCLIC OR AROMATIC OXOACIDS | MERCK PATENT GESELLSCHAFT MIT (DE) | 2000-11-07 | — | — | US | disclosed |
| CN-1227538-A | Pharmaceutical composition containing 4-oxo-butynic acid | MERCK PATENT GMBH (DE) | 1999-09-01 | — | — | CN | disclosed |