Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669374 | 0.90 | LSS (0.44) | LSSKDM4ELMNAMAPK1MEN1 | |
| SCHEMBL7767787 | 0.88 | LSS (0.40) | LSSKDM4ELMNAMAPK1MEN1 | |
| SCHEMBL8047705 | 0.87 | PPARD (0.38) | LSSKDM4ELMNAMAPK1HPGD | |
| SCHEMBL8047273 | 0.87 | IL2 (0.35) | KDM4EACHEALDH1A1 | |
| SCHEMBL8035630 | 0.84 | LSS (0.60) | LSSLMNAMAPK1MEN1KMT2A | |
| SCHEMBL8035731 | 0.82 | KDM4E (0.47) | LSSKDM4ELMNAMEN1KMT2A | |
| SCHEMBL7771933 | 0.82 | LMNA (0.37) | LSSKDM4ELMNAMEN1KMT2A | |
| SCHEMBL8035571 | 0.82 | LSS (0.52) | LSSKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL8035588 | 0.80 | EZH2 (0.35) | LMNAMEN1KMT2AACHE | |
| SCHEMBL8047384 | 0.80 | LSS (0.43) | LSSLMNAMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | claimed |