Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8039625 | 0.89 | AKR1B10 (0.46) | HSD17B10HTR6SMN1; SMN2KDM4EGAA | |
| SCHEMBL8036147 | 0.88 | DRD2 (0.47) | HSD17B10SMN1; SMN2KDM4EBAZ2BDRD2 | |
| SCHEMBL2707877 | 0.74 | MAPKAPK2 (0.62) | SMN1; SMN2BAZ2BKDRMAPKAPK2 | |
| SCHEMBL11355122 | 0.74 | KDM4E (0.51) | HSD17B10KDM4EGAADRD2DRD1 | |
| SCHEMBL8025914 | 0.72 | HSD17B10 (0.57) | HSD17B10HTR6KDM4EPTGS1PTGS2 | |
| SCHEMBL15241465 | 0.72 | MAPT (0.55) | SMN1; SMN2KDM4EGAATSHRMAPKAPK2 | |
| SCHEMBL28476651 | 0.69 | MAOA (0.39) | HSD17B10HTR6KDM4EMAOAMAOB | |
| SCHEMBL8035821 | 0.67 | KMT2A (0.48) | HSD17B10HTR6KDM4EGAAPTGS1 | |
| SCHEMBL3558589 | 0.66 | MAPT (0.51) | HSD17B10KDM4EGAAAKR1C3AKR1C2 | |
| SCHEMBL18052964 | 0.65 | MAPT (0.50) | HSD17B10KDM4EGAAAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | disclosed |