Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL803676 | 0.92 | LMNA (0.50) | KDM4ESMN1; SMN2LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL803088 | 0.92 | KDM4E (0.59) | KDM4ESMN1; SMN2LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL803093 | 0.82 | CHRM4 (0.39) | KDM4ESMN1; SMN2LMNACYP1A2CYP2D6 | |
| SCHEMBL803403 | 0.82 | KDM4E (0.36) | KDM4ESMN1; SMN2LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL803402 | 0.81 | TNKS (0.36) | KDM4ESMN1; SMN2LMNASIGMAR1HRH1 | |
| SCHEMBL13512464 | 0.80 | KDM4E (0.59) | KDM4ESMN1; SMN2LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL14197754 | 0.80 | LMNA (0.60) | KDM4ESMN1; SMN2LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL13512585 | 0.80 | KDM4E (0.61) | KDM4ESMN1; SMN2LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL12776472 | 0.78 | L3MBTL1 (0.58) | KDM4ESMN1; SMN2LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL938062 | 0.78 | L3MBTL1 (0.57) | KDM4ESMN1; SMN2LMNAL3MBTL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | KDM4E 2727/4885SMN1; SMN2 2971/4885LMNA 1463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.