Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL803080 | 0.92 | PDE2A (0.37) | LMNACXCR4CYP1A2CYP2D6 | |
| SCHEMBL803399 | 0.92 | KDM4E (0.40) | KDM4ESMN1; SMN2IKZF2CXCR4CYP2D6 | |
| SCHEMBL803679 | 0.82 | KDM4E (0.53) | KDM4ESMN1; SMN2LMNASIGMAR1CYP1A2 | |
| SCHEMBL803095 | 0.80 | HSD11B1 (0.47) | SIGMAR1HIF1AACHEHSD11B1 | |
| SCHEMBL803402 | 0.80 | TNKS (0.36) | KDM4ESMN1; SMN2IKZF2LMNASIGMAR1 | |
| SCHEMBL803093 | 0.76 | CHRM4 (0.39) | KDM4ESMN1; SMN2LMNACYP1A2CYP2D6 | |
| SCHEMBL803676 | 0.75 | LMNA (0.50) | KDM4ESMN1; SMN2LMNASIGMAR1CYP1A2 | |
| SCHEMBL803677 | 0.74 | KAT2B (0.40) | KDM4ECYP1A2CYP2D6HIF1AACHE | |
| SCHEMBL17289037 | 0.74 | HRH1 (0.44) | KDM4EIKZF2LMNACXCR4CYP1A2 | |
| SCHEMBL17698971 | 0.74 | IKZF2 (0.41) | KDM4ESMN1; SMN2IKZF2CYP1A2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | KDM4E 2727/4885SMN1; SMN2 2971/4885IKZF2 4819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.