Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 4/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ARF6 | P62330 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13886771 | 0.82 | NPC1 (0.48) | NPC1RAB9AKIF11MC4RRXFP1 | |
| SCHEMBL5437448 | 0.81 | SLC6A4 (0.37) | HTR2AHTR2CKCNH2 | |
| SCHEMBL13286195 | 0.79 | KIF11 (0.41) | NPC1RAB9AKIF11ALDH1A1KDM4E | |
| SCHEMBL27770205 | 0.78 | HTR2A (0.32) | KIF11ALDH1A1KDM4EHTR2AHTR2C | |
| SCHEMBL50743 | 0.77 | PARP1 (0.46) | RAB9AKIF11ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL18661421 | 0.76 | CHEK2 (0.42) | RAB9AALDH1A1KDM4ECCR3KMT2A | |
| SCHEMBL84762 | 0.76 | MAOA (0.33) | ALDH1A1KDM4EHTR2AHTR2CKCNH2 | |
| SCHEMBL50237 | 0.76 | PARP1 (0.50) | RAB9AKIF11ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL13792682 | 0.76 | KDM4E (0.49) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL13210438 | 0.75 | HTR2A (0.32) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120070409-A1 | TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070409-A1 | TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR | POLI, TERT, ZC3HAV1 | NPC1 1131/4885RAB9A 2410/4885KIF11 2609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.