SCHEMBL8037671

SCHEMBL8037671

CCCc1cnc(-c2ccc(F)cc2)nc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 1/20 0.49
RAB9A P51151 6/20 0.49
SMN1; SMN2 Q16637 5/20 0.49
NPC1 O15118 5/20 0.49
HTT P42858 1/20 0.49
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
HSD17B10 Q99714 3/20 0.45
KDM4E B2RXH2 2/20 0.45
ALDH1A1 P00352 2/20 0.45
GAA P10253 2/20 0.45
USP2 O75604 1/20 0.45
MAPT P10636 1/20 0.45
HPGD P15428 1/20 0.45
TP53 P04637 2/20 0.44
PKM P14618 1/20 0.44
LMNA P02545 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL785042 0.98 RAB9A (0.51) RARBRAB9ASMN1; SMN2NPC1HTT
SCHEMBL10501596 0.96 RARB (0.47) RARBRAB9ASMN1; SMN2NPC1HTT
SCHEMBL10559916 0.89 RARB (0.57) RARBRAB9ASMN1; SMN2NPC1HTT
SCHEMBL8454712 0.88 RARB (0.56) RARBRAB9ASMN1; SMN2NPC1HTT
SCHEMBL5354918 0.88 RARB (0.64) RARBRAB9ASMN1; SMN2NPC1HTT
SCHEMBL7907395 0.86 RAB9A (0.57) RARBRAB9ASMN1; SMN2NPC1MEN1
SCHEMBL10555573 0.86 RARB (0.67) RARBRAB9ASMN1; SMN2NPC1MEN1
SCHEMBL10558487 0.86 RARB (0.67) RARBRAB9ASMN1; SMN2NPC1MEN1
SCHEMBL4800256 0.86 RARB (0.67) RARBRAB9ASMN1; SMN2NPC1MEN1
SCHEMBL10505564 0.86 RARB (0.67) RARBRAB9ASMN1; SMN2NPC1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-60204769-A None JP disclosed
JP-59184165-A None JP disclosed
EP-0728829-B1 Liquid crystalline alkenylcyclohexene derivative, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-05-03 EP disclosed
EP-0394417-B2 SUPERTWIST LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 1999-08-04 EP disclosed
EP-0438547-B2 SUPER-TWIST LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 1999-07-07 EP disclosed
US-5876626-A HIGH SPEED SWITCHING MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1999-03-02 US disclosed
EP-0494368-B1 Supertwist liquid crystal display MERCK PATENT GMBH (DE) 1999-01-20 EP disclosed
EP-0728829-A2 Liquid crystalline alkenylcyclohexene derivative, liquid crystal composition and liquid crystal display element CHISSO CORPORATION (JP) 1996-08-28 EP disclosed
EP-0471831-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 1996-08-14 EP disclosed
EP-0481293-B1 Supertwist liquid crystal display MERCK PATENT GMBH (DE) 1996-06-05 EP disclosed
EP-0366985-A1 Super twist liquid crystal display MERCK PATENT GmbH (DE) 1990-05-09 EP disclosed
WO-1990004622-A1 SUPERTWIST LIQUID CRYSTAL DISPLAY MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-05-03 WO disclosed
EP-0126949-B1 FLUORINE-CONTAINING PYRIMIDINE DERIVATIVES MERCK PATENT GmbH (DE) 1989-09-27 EP disclosed
EP-0123907-B1 FLUOROPYRIMIDINE DERIVATIVES Chisso Corporation (JP) 1989-07-26 EP disclosed
US-4812258-A LIQUID CRYSTAL DIELECTRICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1989-03-14 US disclosed
US-4581155-A LIQUID CRYSTALS CHISSO CORPORATION (JP) 1986-04-08 US disclosed
JP-S60204769-A HALOGENOPYRIMIDINE DERIVATIVE CHISSO CORP 1985-10-16 JP disclosed
EP-0126949-A2 Fluorine-containing pyrimidine derivatives MERCK PATENT GmbH (DE) 1984-12-05 EP disclosed
EP-0123907-A2 Fluoropyrimidine derivatives Chisso Corporation (JP) 1984-11-07 EP disclosed
JP-S59184165-A 5-ALKYL-2-(4-FLUOROPHENYL)-PYRIMIDINE CHISSO CORP 1984-10-19 JP disclosed