Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15242342 | 0.83 | MMP9 (0.36) | PLA2G2CMMP9MMP8MMP14POLB | |
| SCHEMBL8029912 | 0.81 | PLA2G2C (0.35) | PLA2G2CALDH1A1MMP9MMP8MMP14 | |
| SCHEMBL14638762 | 0.79 | CA1 (0.45) | PLA2G2CALDH1A1MMP9MMP8MMP14 | |
| SCHEMBL13419618 | 0.72 | PRKD3 (0.46) | PLA2G2CALDH1A1LMNATSHR | |
| SCHEMBL9673764 | 0.72 | USP2 (0.54) | PLA2G2CLMNAMAPT | |
| SCHEMBL9674744 | 0.72 | USP2 (0.54) | PLA2G2CLMNAMAPT | |
| SCHEMBL9496605 | 0.72 | USP2 (0.54) | PLA2G2CLMNAMAPT | |
| SCHEMBL9674613 | 0.72 | USP2 (0.54) | PLA2G2CLMNAMAPT | |
| SCHEMBL13841203 | 0.71 | USP2 (0.52) | PLA2G2CALDH1A1TSHRHPGDATM | |
| SCHEMBL7928161 | 0.71 | USP2 (0.52) | PLA2G2CALDH1A1TSHRHPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170015704-A1 | AMINOTHIAZOLES AND THEIR USES | NOVARTIS AG (CH) | 2017-01-19 | — | — | US | disclosed |
| US-9492496-B2 | Aminothiazoles and their uses | NOVARTIS AG (CH) | 2016-11-15 | — | — | US | disclosed |
| US-20140274878-A1 | AMINOTHIAZOLES AND THEIR USES | NOVARTIS AG (CH) | 2014-09-18 | — | — | US | disclosed |
| US-20130231275-A1 | AMINIOTHIAZOLES AND THEIR USES | NOVARTIS AG (CH) | 2013-09-05 | — | — | US | disclosed |
| WO-2009074605-A1 | AMINOTHIAZOLES AND THEIR USES | NOVARTIS AG (CH) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231275-A1 | AMINIOTHIAZOLES AND THEIR USES | ABAT, AADAT, AADAC | PLA2G2C 3779/4885ALDH1A1 210/4885LMNA 2481/4885 |
| US-20170015704-A1 | AMINOTHIAZOLES AND THEIR USES | ABAT, AADAT, BCAT2 | PLA2G2C 3161/4885ALDH1A1 438/4885LMNA 4122/4885 |
| US-20140274878-A1 | AMINOTHIAZOLES AND THEIR USES | ABAT, AADAT, BCAT2 | PLA2G2C 3161/4885ALDH1A1 438/4885LMNA 4122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.