Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027588 | 0.81 | HTT (0.66) | HTTRAB9AGAAMAPTMAPK1 | |
| SCHEMBL23714535 | 0.79 | HTT (0.54) | HTTRAB9AGAAMAPTMAPK1 | |
| SCHEMBL48578 | 0.79 | HTT (0.64) | HTTRAB9AGAAMAPTMAPK1 | |
| SCHEMBL17178075 | 0.79 | CA9 (0.54) | HTTRAB9AGAAMAPTMAPK1 | |
| SCHEMBL19319057 | 0.79 | RAB9A (0.54) | HTTRAB9AGAAMAPTMAPK1 | |
| SCHEMBL8299549 | 0.78 | ALOX12 (0.56) | GAAMAPTLMNAALDH1A1CA9 | |
| SCHEMBL13558235 | 0.77 | ALDH1A1 (0.64) | HTTGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL24568371 | 0.77 | NAMPT (0.52) | HTTRAB9AMAPTMAPK1LMNA | |
| SCHEMBL20924880 | 0.77 | POLB (0.46) | RAB9AGAAMAPTMAPK1LMNA | |
| SCHEMBL13369666 | 0.77 | SMN1; SMN2 (0.53) | RAB9AGAAMAPTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427451-B1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2887943-B1 | NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES | VIROSTATICS SRL (IT) | 2017-12-06 | — | — | EP | disclosed |
| EP-1480962-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-24 | — | — | EP | disclosed |
| WO-2009052138-A1 | PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |