SCHEMBL8040072

SCHEMBL8040072

O=C1CCC(C2CC[Si](c3ccccc3)(c3ccccc3)CC2)CC1

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
CYP2C9 P11712 1/20 0.33
ESR2 Q92731 1/20 0.32
DDB1 Q16531 2/20 0.30
CRBN Q96SW2 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7758021 0.81 ACHE (0.31) MEN1KMT2ACYP2C9
SCHEMBL8034657 0.80 MEN1 (0.40) MEN1KMT2ACYP2C9
SCHEMBL8015888 0.79 NPC1 (0.33) KMT2A
SCHEMBL7755549 0.78
SCHEMBL7756311 0.76
SCHEMBL8015518 0.75 MT-CO2 (0.43)
SCHEMBL8449305 0.74 MEN1 (0.32) MEN1KMT2A
SCHEMBL8837083 0.74 NFKB1 (0.31)
SCHEMBL8451929 0.73
SCHEMBL7755593 0.73 KCNH2 (0.32) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0687678-B1 Cyclohexanone compounds, process for preparing the same, and processes for preparing silacyclohexane-based liquid crystal compounds from the cyclohexanone compounds SHINETSU CHEMICAL CO (JP) 2000-03-22 EP disclosed
US-6004478-A LIQUID CRYSTAL SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-12-21 US disclosed
US-5693841-A Cyclohexanone compounds, process for preparing the same, and processes for preparing silacyclohexane-based liquid crystal compounds from the cyclohexanone compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-12-02 US disclosed
EP-0765880-A1 Process for preparing sil acyclohexane-based liquid crystal compounds from silacyclohexanone compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-04-02 EP disclosed
EP-0732335-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-09-18 EP disclosed
US-5523439-A Process for preparing silacyclohexane compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-04 US disclosed
EP-0696592-A1 Process for preparing silacyclohexane compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-02-14 EP disclosed
EP-0687678-A1 Cyclohexanone compounds, process for preparing the same, and processes for preparing silacyclohexane-based liquid crystal compounds from the cyclohexanone compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1995-12-20 EP disclosed