SCHEMBL8040586

SCHEMBL8040586

C[Si](Cl)(c1ccccc1)c1ccc([Si](C)(Cl)c2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.48
ESR2 Q92731 1/20 0.48
NR1H2 P55055 2/20 0.39
NR1H3 Q13133 2/20 0.39
TSHR P16473 2/20 0.33
LMNA P02545 1/20 0.33
ALOX12 P18054 1/20 0.33
ACHE P22303 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.32
ALDH1A1 P00352 2/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
KMT2A Q03164 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NR1I2 O75469 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL197544 0.97 ESR1 (0.44) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL10319247 0.92 ESR1 (0.43) ESR1ESR2NR1H2NR1H3ACHE
SCHEMBL23211688 0.92 ESR1 (0.41) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL10319854 0.90 ACHE (0.46) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL10319284 0.84 CA4 (0.52) LMNAACHEALDH1A1TDP1KMT2A
SCHEMBL10320598 0.84 ALDH1A1 (0.46) ESR1ESR2TSHRLMNAMAPT
SCHEMBL10319681 0.84 ESR1 (0.38) ESR1ESR2LMNAMAPTTDP1
SCHEMBL10318823 0.84 NR1H2 (0.43) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL10317741 0.84 LTA4H (0.50) NR1H2TSHRLMNASMN1; SMN2
SCHEMBL10319292 0.84 TP53 (0.52) ESR1ESR2TSHRLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-60047026-A None JP disclosed
JP-61118745-A None JP disclosed
EP-0661332-B1 Silicon-containing reactive polymer and curable resin composition comprising the same KANEGAFUCHI CHEMICAL IND (JP) 2000-04-12 EP disclosed
US-6025117-A USING POLYSILANE COPOLYMER OR DENDRIMER FILM PATTERN AS MASK FOR ETCHING INSULATING OR CONDUCTING LAYER ON SUBSTRATE KABUSHIKI KAISHA TOSHIBA (JP) 2000-02-15 US disclosed
EP-0673960-B1 Method for producing polysilanes OSAKA GAS CO LTD (JP) 1999-12-08 EP disclosed
US-5641849-A Method for producing polysilanes OSAKA GAS COMPANY LIMITED (JP) 1997-06-24 US disclosed
EP-0673960-A1 Method for producing polysilanes OSAKA GAS CO., LTD. (JP) 1995-09-27 EP disclosed
EP-0661332-A2 Silicon-containing reactive polymer and curable resin composition comprising the same Kanegafuchi Chemical Industry Co., Ltd. (JP) 1995-07-05 EP disclosed
EP-0129834-B1 PHOTO AND RADIATION-SENSITIVE ORGANOPOLYMERIC MATERIAL HITACHI, LTD. (JP) 1988-03-23 EP disclosed
JP-S61118745-A LIGHT ND RADIATION SENSITIVE ORGANIC POLYMER HITACHI LTD 1986-06-06 JP disclosed
US-4544729-A Photo and radiation-sensitive organopolymeric material HITACHI, LTD. (JP) 1985-10-01 US disclosed
JP-S6047026-A NOVEL POLYMER HITACHI LTD 1985-03-14 JP disclosed