Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cycloheptanamine SCHEMBL7801780 | 0.89 | EPHX1 (0.36) | EPHX1RPS6KA3JAK3CNR1GPR35 | |
| Cyclohexylamine SCHEMBL7792374 | 0.89 | EPHX1 (0.36) | EPHX1RPS6KA3JAK3CNR1GPR35 | |
| Cyclohexylamine SCHEMBL8035100 | 0.88 | POLB (0.42) | EPHX1PTGDR2CCR2POLBRAB9A | |
| Cyclohexylamine SCHEMBL8025513 | 0.87 | DPEP1 (0.43) | PTGDR2DPEP1 | |
| Cyclohexylamine SCHEMBL8025629 | 0.87 | EPHX1 (0.40) | EPHX1PTGDR2FFAR4TACR1RPS6KA3 | |
| Cyclohexylamine SCHEMBL8025626 | 0.87 | EPHX1 (0.40) | EPHX1PTGDR2FFAR4TACR1RPS6KA3 | |
| Glycine SCHEMBL8212592 | 0.86 | RPS6KA3 (0.44) | FFAR4RPS6KA3JAK3LMNARXRA | |
| Lysine SCHEMBL8035212 | 0.82 | GSR (0.42) | EPHX1TACR1DPEP1 | |
| Lysine SCHEMBL8035214 | 0.82 | GSR (0.42) | EPHX1TACR1DPEP1 | |
| Cyclohexylamine SCHEMBL7798494 | 0.80 | GRN (0.36) | EPHX1PTGDR2FFAR4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |